Biologics and HAE

Does anyone know if Biologics have been researched specifically on HAE patients?

I have documented allergies to four different biologics - TNF blockers to be specific - causing the rare symptom of severe swelling everywhere, including my throat and chest.
These swelling episodes are also well known as normal for sufferers of Hereditary Angioedema.

My question is:

Are TNF blockers causing a true-to-form allergy, causing swelling, or do these medications have an ingredient or a mechanism that specifically interacts or exacerbates Hereditary Angioedema?
Is this an allergy or an INTOLERANCE based on the fact that I have Hereditary Angioedema?

And further - if it is simply that the medication includes something that triggers HAE, can we fix it? Can these Biologics be tweaked to be available to HAE patients - especially those who also suffer from several autoimmune conditions who may very well benefit from the use of biologics??

Is there someone in medication scientific research willing to investigate this potential correlation?